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簡要描述:37215壓力測試儀是經(jīng)典的7200paw壓力測試儀的升級產(chǎn)品,自1965年使用以來,該測試儀在多個學術(shù)和工業(yè)實驗室為鎮(zhèn)痛藥物的開發(fā)和研究做出了貢獻
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37215壓力測試儀是經(jīng)典的7200 paw壓力測試儀的升級產(chǎn)品,自1965年使用以來,該測試儀在多個學術(shù)和工業(yè)實驗室為鎮(zhèn)痛藥物的開發(fā)和研究做出了貢獻。
壓痛儀的主要特點:
· 提供三種測試量程:250g,500g,750g
· 簡單可靠:無需校準!
· 標準為砝碼測試型號,可根據(jù)需要選擇數(shù)字顯示型號;
· 提供小鼠專用型號,測量更準確;
· 1960年代以來的經(jīng)典方法:發(fā)表論文數(shù)百篇!
型號:37215型
· 爪子放置在帶有圓形的錐形推動器下方的小底座上;
· 操作人員按下踏板開關(guān),壓力由小到大施加到動物的爪子上;
· 力以恒定速率增加,使得測試具備很好的可重復(fù)性;
· 動物感受到疼痛時會產(chǎn)生躲避反應(yīng);
· 松開踏板開關(guān),壓力立即停止;
· 在以10g為步進單位施加力;
· 采用低壓同步電機,符合CE規(guī)則;
· 根據(jù)需要,可選擇小鼠專用的型號;
· 數(shù)顯型號更容易記錄數(shù)據(jù)和讀取數(shù)據(jù);
· 傳統(tǒng)款式和數(shù)顯款式采用箱體的測試結(jié)構(gòu),測量數(shù)據(jù)一致;
· 數(shù)字顯示器采用模塊化設(shè)計,可以對傳統(tǒng)款式進行升級;
37215型壓痛儀的主要規(guī)格
· 電源:115或230V,50/60Hz
· 功率:15W
· 操控方式:踏板開關(guān)
· 尺寸:40 x 16 x 14cm
· 重量:2.1Kg
型號和測試量程
· 37215,大鼠小鼠通用型:250g,500g,750g
· 37216,小鼠型號:125g,250g,375g
壓力模塊
參考文獻:
1.Baloh, Robert H et al. “Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial." Nature
medicine vol. 28,9 (2022): 1813-1822. doi:10.1038/s41591-022-01956-3
2.Bosse, Gabriel D et al. “The 5α-reductase inhibitor finasteride reduces opioid self-administration in animal models of opioid use disorder." The Journal of clinical
investigation vol. 131,10 (2021): e143990. doi:10.1172/JCI143990
3.Bang, Sangsu et al. “GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain." The Journal of clinical investigation vol. 128,8 (2018):
3568-3582. doi:10.1172/JCI99888
4.Goebel, Andreas et al. “Passive transfer of fibromyalgia symptoms from patients to mice." The Journal of clinical investigation vol. 131,13 (2021): e144201.
doi:10.1172/JCI144201
5.Sikandar, Shafaq et al. “Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain." Brain : a journal of neurology vol. 141,4
(2018): 1028-1039. doi:10.1093/brain/awy009
6.Vidal-Torres, Alba et al. “Bispecific sigma-1 receptor antagonism and mu-opioid receptor partial agonism: WLB-73502, an analgesic with improved efficacy and
safety profile compared to strong opioids." Acta pharmaceutica Sinica. B vol. 13,1 (2023): 82-99. doi:10.1016/j.apsb.2022.09.018
7.Mousa, Shaaban A et al. “Superior control of inflammatory pain by corticotropin-releasing factor receptor 1 via opioid peptides in distinct pain-relevant brain
areas." Journal of neuroinflammation vol. 19,1 148. 15 Jun. 2022, doi:10.1186/s12974-022-02498-8
8.Zhou, Danli et al. “Inhibition of apoptosis signal-regulating kinase by paeoniflorin attenuates neuroinflammation and ameliorates neuropathic pain." Journal of
neuroinflammation vol. 16,1 83. 11 Apr. 2019, doi:10.1186/s12974-019-1476-6
9.Wang, Wenying et al. “Exchange factor directly activated by cAMP-PKCε signalling mediates chronic morphine-induced expression of purine P2X3 receptor in rat
dorsal root ganglia." British journal of pharmacology vol. 175,10 (2018): 1760-1769. doi:10.1111/bph.14191
10.Sala, Emanuele et al. “Improved efficacy, tolerance, safety, and abuse liability profile of the combination of CR4056 and morphine over morphine alone in rodent
models." British journal of pharmacology vol. 177,14 (2020): 3291-3308. doi:10.1111/bph.15049
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